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Results: The primary outcome (composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke) occurred in 6.6% of patients in the semaglutide group and 8.9% in the placebo group, indicating a 26% lower risk with semaglutide
This notion is speculative at present, as no change in cognition was observed in one small RCT of exenatide in schizophrenia 140 , while a positive cognitive effect of liraglutide was only seen in an even smaller non-randomized open-label investigation of people with either depressive or bipolar disorders 178,179
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This slow yet steady increase allows semaglutide to continue to work as designed while minimizing potential side effects
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